项目名称： 牛磺酸在环境代谢因素致维、哈2型糖尿病中的作用评价及调控机制研究

项目编号： No.81460493

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 马晓丽

作者单位： 新疆医科大学

项目金额： 45万元

中文摘要： 糖尿病对患者的消耗性影响已成为紧迫的全球健康问题。新疆维吾尔族 2 型糖尿病患病率高达14%，而哈萨克族2型糖尿病患病率仅1％，研究适时干预策略对地区糖尿病防治具有重要社会经济意义。本课题通过前期的代谢组学研究发现体液中牛磺酸水平改变可能与维、哈2型糖尿病不同发病率有关，目前国际上也在开展外源补充牛磺酸从而改善高血压、冠心病的研究。本课题运用基于NMR及LC-MS的代谢组学技术开展新疆维、哈两民族2型糖尿病体液牛磺酸水平的比较研究，通过多元分析探索牛磺酸在不同饮食结构民族2型糖尿病血糖血脂影响中的作用；构建高糖、高脂诱发的2型糖尿病大鼠模型，通过牛磺酸干预评估其对2型糖尿病大鼠血糖、血脂水平及对体液、组织中牛磺酸水平的纠正影响，通过以上研究正确地评价和了解牛磺酸在机体糖、脂代谢中的地位和作用层次及对糖尿病预防作用的机制。为寻找外源性营养补充剂拮抗糖尿病这一推理提供理论和实验依据。

中文关键词： 牛磺酸；环境代谢；2型糖尿病；营养干预；调控机制

英文摘要： Diabetes is one of the major disease which threatened human health.It has important significance to give the earlier effective intervention because of the high rates of type 2 diabetes in Uygur 14%,although only 1% in Kazak subjects in xinjiang.From our study,the high performance liquid chromatography -tandem mass spectrometry and NMR were used to investigate the amino acid metabolic in diabetes patients ,we found that the level of taurine in plasm and urine were both decreased in type 2 diabetes patients than in healty volunteers.this result different from the previous study that taurine level was higher in urine of Kazak .our project will use the LC/MS and NMR tech to investigate the difference between the two ethic groups by using the multivapd analytical method to identified the role of taurine in the progress of type 2 diabetes.then ,T2DM diabetic rats model will made by high fat food and STZ,From given the different dose of taurine ,the index combined with glucose and fat metablism will be detected and the potential key role of taruine in the pathogenesis of diabetes will be clear .in the result ,our study will suggest that if taurine can prevent diabetes and improve the glucose and fat metabolism.

英文关键词： taurine;enviromental metabolism;type 2 diabetes;Nutrition Intervention;regulation mechanism