This paper presents a novel hybrid approach to solving real-world drone routing problems by leveraging the capabilities of quantum computing. The proposed method, coined Quantum for Drone Routing (Q4DR), integrates the two most prominent paradigms in the field: quantum gate-based computing, through the Eclipse Qrisp programming language; and quantum annealers, by means of D-Wave System's devices. The algorithm is divided into two different phases: an initial clustering phase executed using a Quantum Approximate Optimization Algorithm (QAOA), and a routing phase employing quantum annealers. The efficacy of Q4DR is demonstrated through three use cases of increasing complexity, each incorporating real-world constraints such as asymmetric costs, forbidden paths, and itinerant charging points. This research contributes to the growing body of work in quantum optimization, showcasing the practical applications of quantum computing in logistics and route planning.

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