Multi-modal brain images from MRI scans are widely used in clinical diagnosis to provide complementary information from different modalities. However, obtaining fully paired multi-modal images in practice is challenging due to various factors, such as time, cost, and artifacts, resulting in modality-missing brain images. To address this problem, unsupervised multi-modal brain image translation has been extensively studied. Existing methods suffer from the problem of brain tumor deformation during translation, as they fail to focus on the tumor areas when translating the whole images. In this paper, we propose an unsupervised tumor-aware distillation teacher-student network called UTAD-Net, which is capable of perceiving and translating tumor areas precisely. Specifically, our model consists of two parts: a teacher network and a student network. The teacher network learns an end-to-end mapping from source to target modality using unpaired images and corresponding tumor masks first. Then, the translation knowledge is distilled into the student network, enabling it to generate more realistic tumor areas and whole images without masks. Experiments show that our model achieves competitive performance on both quantitative and qualitative evaluations of image quality compared with state-of-the-art methods. Furthermore, we demonstrate the effectiveness of the generated images on downstream segmentation tasks. Our code is available at https://github.com/scut-HC/UTAD-Net.

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