The unprecedented developments in segmentation foundational models have become a dominant force in the field of computer vision, introducing a multitude of previously unexplored capabilities in a wide range of natural images and videos. Specifically, the Segment Anything Model (SAM) signifies a noteworthy expansion of the prompt-driven paradigm into the domain of image segmentation. The recent introduction of SAM2 effectively extends the original SAM to a streaming fashion and demonstrates strong performance in video segmentation. However, due to the substantial distinctions between natural and medical images, the effectiveness of these models on biomedical images and videos is still under exploration. This paper presents an overview of recent efforts in applying and adapting SAM2 to biomedical images and videos. The findings indicate that while SAM2 shows promise in reducing annotation burdens and enabling zero-shot segmentation, its performance varies across different datasets and tasks. Addressing the domain gap between natural and medical images through adaptation and fine-tuning is essential to fully unleash SAM2's potential in clinical applications. To support ongoing research endeavors, we maintain an active repository that contains up-to-date SAM & SAM2-related papers and projects at https://github.com/YichiZhang98/SAM4MIS.

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