The deepfake threats to society and cybersecurity have provoked significant public apprehension, driving intensified efforts within the realm of deepfake video detection. Current video-level methods are mostly based on {3D CNNs} resulting in high computational demands, although have achieved good performance. This paper introduces an elegantly simple yet effective strategy named Thumbnail Layout (TALL), which transforms a video clip into a pre-defined layout to realize the preservation of spatial and temporal dependencies. This transformation process involves sequentially masking frames at the same positions within each frame. These frames are then resized into sub-frames and reorganized into the predetermined layout, forming thumbnails. TALL is model-agnostic and has remarkable simplicity, necessitating only minimal code modifications. Furthermore, we introduce a graph reasoning block (GRB) and semantic consistency (SC) loss to strengthen TALL, culminating in TALL++. GRB enhances interactions between different semantic regions to capture semantic-level inconsistency clues. The semantic consistency loss imposes consistency constraints on semantic features to improve model generalization ability. Extensive experiments on intra-dataset, cross-dataset, diffusion-generated image detection, and deepfake generation method recognition show that TALL++ achieves results surpassing or comparable to the state-of-the-art methods, demonstrating the effectiveness of our approaches for various deepfake detection problems. The code is available at https://github.com/rainy-xu/TALL4Deepfake.

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