Implantable retinal prostheses offer a promising solution to restore partial vision by circumventing damaged photoreceptor cells in the retina and directly stimulating the remaining functional retinal cells. However, the information transmission between the camera and retinal cells is often limited by the low resolution of the electrode array and the lack of specificity for different ganglion cell types, resulting in suboptimal stimulations. In this work, we propose to utilize normalizing flow-based conditional invertible neural networks to optimize retinal implant stimulation in an unsupervised manner. The invertibility of these networks allows us to use them as a surrogate for the computational model of the visual system, while also encoding input camera signals into optimized electrical stimuli on the electrode array. Compared to other methods, such as trivial downsampling, linear models, and feed-forward convolutional neural networks, the flow-based invertible neural network and its conditional extension yield better visual reconstruction qualities w.r.t. various metrics using a physiologically validated simulation tool.

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