This paper investigates the optimization problem of scheduling autonomous mobile robots (AMRs) in hospital settings, considering dynamic requests with different priorities. The primary objective is to minimize the daily service cost by dynamically planning routes for the limited number of available AMRs. The total cost consists of AMR's purchase cost, transportation cost, delay penalty cost, and loss of denial of service. To address this problem, we have established a two-stage mathematical programming model. In the first stage, a tabu search algorithm is employed to plan prior routes for all known medical requests. The second stage involves planning for real-time received dynamic requests using the efficient insertion algorithm with decision rules, which enables quick response based on the time window and demand constraints of the dynamic requests. One of the main contributions of this study is to make resource allocation decisions based on the present number of service AMRs for dynamic requests with different priorities. Computational experiments using Lackner instances demonstrate the efficient insertion algorithm with decision rules is very fast and robust in solving the dynamic AMR routing problem with time windows and request priority. Additionally, we provide managerial insights concerning the AMR's safety stock settings, which can aid in decision-making processes.

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