Both smart propagation engineering as well as integrated sensing and communication (ISAC) constitute promising candidates for next-generation (NG) mobile networks. We provide a synergistic view of these technologies, and explore their mutual benefits. First, moving beyond just intelligent surfaces, we provide a holistic view of the engineering aspects of smart propagation environments. By delving into the fundamental characteristics of intelligent surfaces, fluid antennas, and unmanned aerial vehicles, we reveal that more efficient control of the pathloss and fading can be achieved, thus facilitating intrinsic integration and mutual assistance between sensing and communication functionalities. In turn, with the exploitation of the sensing capabilities of ISAC to orchestrate the efficient configuration of radio environments, both the computational effort and signaling overheads can be reduced. We present indicative simulation results, which verify that cooperative smart propagation environment design significantly enhances the ISAC performance. Finally, some promising directions are outlined for combining ISAC with smart propagation engineering.

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