For a multi-attribute decision making (MADM) problem, the information of alternatives under different attributes is given in the form of intuitionistic fuzzy number(IFN). Intuitionistic fuzzy set (IFS) plays an important role in dealing with un-certain and incomplete information. The similarity measure of intuitionistic fuzzy sets (IFSs) has always been a research hotspot. A new similarity measure of IFSs based on the projection technology and cosine similarity measure, which con-siders the direction and length of IFSs at the same time, is first proposed in this paper. The objective of the presented pa-per is to develop a MADM method and medical diagnosis method under IFS using the projection technology and cosine similarity measure. Some examples are used to illustrate the comparison results of the proposed algorithm and some exist-ing methods. The comparison result shows that the proposed algorithm is effective and can identify the optimal scheme accurately. In medical diagnosis area, it can be used to quickly diagnose disease. The proposed method enriches the exist-ing similarity measure methods and it can be applied to not only IFSs, but also other interval-valued intuitionistic fuzzy sets(IVIFSs) as well.

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