In industrial and IoT environments, massive amounts of real-time and historical process data are continuously generated and archived. With sensors and devices capturing every operational detail, the volume of time-series data has become a critical challenge for storage and processing systems. Efficient data management is essential to ensure scalability, cost-effectiveness, and timely analytics. To minimize storage expenses and optimize performance, data compression algorithms are frequently utilized in data historians and acquisition systems. However, compression comes with trade-offs that may compromise the accuracy and reliability of engineering analytics that depend on this compressed data. Understanding these trade-offs is essential for developing data strategies that support both operational efficiency and accurate, reliable analytics. This paper assesses the relation of common compression mechanisms used in real-time and historical data systems and the accuracy of analytical solutions, including statistical analysis, anomaly detection, and machine learning models. Through theoretical analysis, simulated signal compression, and empirical assessment, we illustrate that excessive compression can lose critical patterns, skew statistical measures, and diminish predictive accuracy. The study suggests optimum methods and best practices for striking a compromise between analytical integrity and compression efficiency.

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