Experimental data in Particle and Nuclear physics, Particle Astrophysics and Radiation Protection Dosimetry are obtained from experimental facilities comprising a complex array of sensors, electronics and software. Computer simulation is used to study the measurement process. Probability Density Functions (PDFs) of measured physical parameters deviate from true PDFs due to resolution, bias, and efficiency effects. Good estimates of the true PDF are necessary for testing theoretical models, comparing results from different experiments, and combining results from various research endeavors. In the article, the histogram method is employed to estimate both the measured and true PDFs. The binning of histograms is determined using the K-means clustering algorithm. The true PDF is estimated through the maximization of the likelihood function with entropy regularization, utilizing a non-linear optimization algorithm specially designed for this purpose. The accuracy of the results is assessed using the Mean Integrated Square Error. To determine the optimal value for the regularization parameter, a bootstrap method is applied. Additionally, a mathematical model of the measurement system is formulated using system identification methods. This approach enhances the robustness and precision of the estimation process, providing a more reliable analysis of the system's characteristics.

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