In this paper, we study the well-posedness and regularity of non-autonomous stochastic differential algebraic equations (SDAEs) with nonlinear, locally Lipschitz and monotone (2) coefficients of the form (1). The main difficulty is the fact that the operator A(.) is non-autonomous, i.~e. depends on t and the matrix $A(t)$ is singular for all $t\in \left[0,T\right]$. Our interest is in SDAE of index-1. This means that in order to solve the problem, we can transform the initial SDAEs into an ordinary stochastic differential equation with algebraic constraints. Under appropriate hypothesizes, the main result establishes the existence and uniqueness of the solution in $\mathcal{M}^p(\left[0, T\right], \mathbb{R}^n)$, $p\geq 2$, $p\in \mathbb{N}$. Several strong estimations and regularity results are also provided. Note that, in this paper, we use various techniques such as It\^o's lemma, Burkholder-Davis-Gundy inequality, and Young inequality.

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