Multi-agent systems, powered by large language models, have shown great abilities across various tasks due to the collaboration of expert agents, each focusing on a specific domain. However, when agents are deployed separately, there is a risk that malicious users may introduce malicious agents who generate incorrect or irrelevant results that are too stealthy to be identified by other non-specialized agents. Therefore, this paper investigates two essential questions: (1) What is the resilience of various multi-agent system structures (e.g., A$\rightarrow$B$\rightarrow$C, A$\leftrightarrow$B$\leftrightarrow$C) under malicious agents, on different downstream tasks? (2) How can we increase system resilience to defend against malicious agents? To simulate malicious agents, we devise two methods, AutoTransform and AutoInject, to transform any agent into a malicious one while preserving its functional integrity. We run comprehensive experiments on four downstream multi-agent systems tasks, namely code generation, math problems, translation, and text evaluation. Results suggest that the "hierarchical" multi-agent structure, i.e., A$\rightarrow$(B$\leftrightarrow$C), exhibits superior resilience with the lowest performance drop of $23.6\%$, compared to $46.4\%$ and $49.8\%$ of other two structures. Additionally, we show the promise of improving multi-agent system resilience by demonstrating that two defense methods, introducing a mechanism for each agent to challenge others' outputs, or an additional agent to review and correct messages, can enhance system resilience. Our code and data are available at https://github.com/CUHK-ARISE/MAS-Resilience.

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