Relying on paired synthetic data, existing learning-based Computational Aberration Correction (CAC) methods are confronted with the intricate and multifaceted synthetic-to-real domain gap, which leads to suboptimal performance in real-world applications. In this paper, in contrast to improving the simulation pipeline, we deliver a novel insight into real-world CAC from the perspective of Unsupervised Domain Adaptation (UDA). By incorporating readily accessible unpaired real-world data into training, we formalize the Domain Adaptive CAC (DACAC) task, and then introduce a comprehensive Real-world aberrated images (Realab) dataset to benchmark it. The setup task presents a formidable challenge due to the intricacy of understanding the target aberration domain. To this intent, we propose a novel Quntized Domain-Mixing Representation (QDMR) framework as a potent solution to the issue. QDMR adapts the CAC model to the target domain from three key aspects: (1) reconstructing aberrated images of both domains by a VQGAN to learn a Domain-Mixing Codebook (DMC) which characterizes the degradation-aware priors; (2) modulating the deep features in CAC model with DMC to transfer the target domain knowledge; and (3) leveraging the trained VQGAN to generate pseudo target aberrated images from the source ones for convincing target domain supervision. Extensive experiments on both synthetic and real-world benchmarks reveal that the models with QDMR consistently surpass the competitive methods in mitigating the synthetic-to-real gap, which produces visually pleasant real-world CAC results with fewer artifacts. Codes and datasets will be made publicly available.

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