Leverage score sampling is crucial to the design of randomized algorithms for large-scale matrix problems, while the computation of leverage scores is a bottleneck of many applications. In this paper, we propose a quantum algorithm to accelerate this useful method. The speedup is at least quadratic and could be exponential for well-conditioned matrices. We also prove some quantum lower bounds, which suggest that our quantum algorithm is close to optimal. As an application, we propose a new quantum algorithm for rigid regression problems with vector solution outputs. It achieves polynomial speedups over the best classical algorithm known. In this process, we give an improved randomized algorithm for rigid regression.

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