LASSO introduces shrinkage bias into estimated coefficients, which can adversely affect the desirable asymptotic normality and invalidate the standard inferential procedure based on the $t$-statistic. The desparsified LASSO has emerged as a well-known remedy for this issue. In the context of high dimensional predictive regression, the desparsified LASSO faces an additional challenge: the Stambaugh bias arising from nonstationary regressors. To restore the standard inferential procedure, we propose a novel estimator called IVX-desparsified LASSO (XDlasso). XDlasso eliminates the shrinkage bias and the Stambaugh bias simultaneously and does not require prior knowledge about the identities of nonstationary and stationary regressors. We establish the asymptotic properties of XDlasso for hypothesis testing, and our theoretical findings are supported by Monte Carlo simulations. Applying our method to real-world applications from the FRED-MD database -- which includes a rich set of control variables -- we investigate two important empirical questions: (i) the predictability of the U.S. stock returns based on the earnings-price ratio, and (ii) the predictability of the U.S. inflation using the unemployment rate.

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