In this paper we consider the influence of intercellular communication on the development and progression of Glioblastoma Multiforme (GBM), a grade IV malignant glioma which is defined by an interplay Grow i.e. self renewal and Go i.e. invasiveness potential of multiple malignant glioma stem cells. Firstly, we performed wet lab experiments with U87 malignant glioma cells to study the node-stem growth pattern of GBM. Next we develop a model accounting for the structural influence of multiple transmitter and receiver glioma stem cells resulting in the node-stem growth structure of GBM tumour. By using information theory we study different properties associated with this communication model to show that the growth of GBM in a particular direction (node to stem) is related to an increase in mutual information. We further show that information flow between glioblastoma cells for different levels of invasiveness vary at different points between node and stem. These findings are expected to contribute significantly in the design of future therapeutic mechanisms for GBM.

翻译：在本文中,我们考虑了细胞间交流对Glioblastoma Multiforme(GBM)的发展和进展的影响,Glioblastoma Multiforme(GBM)是四级恶性微粒,由一种相互作用定义,即自我更新和Go,即多重恶性微粒干细胞的侵入潜力。首先,我们与U87恶性微粒细胞进行了湿实验室实验,以研究GBM的节点增长模式。接着,我们为多个发报机和接收机的液态干细胞的结构影响制定了一个模型,从而导致GBM肿瘤的节静增长结构。我们利用信息理论研究与这一交流模式相关的不同属性,以表明GBM在特定方向(节点到干点)的成长与相互信息的增加有关。我们进一步表明,不同入侵程度的Gliblastuma细胞之间的信息流动在不同点和干点之间各不相同。这些结果预计将对GBM的未来治疗机制的设计作出重大贡献。