Neural networks achieve state-of-the-art performance in image classification, speech recognition, scientific analysis and many more application areas. With the ever-increasing need for faster computation and lower power consumption, driven by real-time systems and Internet-of-Things (IoT) devices, FPGAs have emerged as suitable devices for deep learning inference. Due to the high computational complexity and memory footprint of neural networks, various compression techniques, such as pruning, quantization and knowledge distillation, have been proposed in literature. Pruning sparsifies a neural network, reducing the number of multiplications and memory. However, pruning often fails to capture properties of the underlying hardware, causing unstructured sparsity and load-balance inefficiency, thus bottlenecking resource improvements. We propose a hardware-centric formulation of pruning, by formulating it as a knapsack problem with resource-aware tensor structures. The primary emphasis is on real-time inference, with latencies in the order of 1$\mu$s, accelerated with hls4ml, an open-source framework for deep learning inference on FPGAs. Evaluated on a range of tasks, including real-time particle classification at CERN's Large Hadron Collider and fast image classification, the proposed method achieves a reduction ranging between 55% and 92% in the utilization of digital signal processing blocks (DSP) and up to 81% in block memory (BRAM) utilization.

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