In recent years, there has been significant development of autonomous vehicle (AV) technologies. However, despite the notable achievements of some industry players, a strong and appealing body of evidence that demonstrate AVs are actually safe is lacky, which could foster public distrust in this technology and further compromise the entire development of this industry, as well as related social impacts. To improve the safety of AVs, several techniques are proposed that use synthetic data in virtual simulation. In particular, the highest risk data, known as corner cases (CCs), are the most valuable for developing and testing AV controls, as they can expose and improve the weaknesses of these autonomous systems. In this context, the present paper presents a systematic literature review aiming to comprehensively analyze methodologies for CC identifi cation and generation, also pointing out current gaps and further implications of synthetic data for AV safety and reliability. Based on a selection criteria, 110 studies were picked from an initial sample of 1673 papers. These selected paper were mapped into multiple categories to answer eight inter-linked research questions. It concludes with the recommendation of a more integrated approach focused on safe development among all stakeholders, with active collaboration between industry, academia and regulatory bodies.

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