In many real-world problems, predictions are leveraged to monitor and control cyber-physical systems, demanding guarantees on the satisfaction of reliability and safety requirements. However, predictions are inherently uncertain, and managing prediction uncertainty presents significant challenges in environments characterized by complex dynamics and forking trajectories. In this work, we assume access to a pre-designed probabilistic implicit or explicit sequence model, which may have been obtained using model-based or model-free methods. We introduce probabilistic time series-conformal risk prediction (PTS-CRC), a novel post-hoc calibration procedure that operates on the predictions produced by any pre-designed probabilistic forecaster to yield reliable error bars. In contrast to existing art, PTS-CRC produces predictive sets based on an ensemble of multiple prototype trajectories sampled from the sequence model, supporting the efficient representation of forking uncertainties. Furthermore, unlike the state of the art, PTS-CRC can satisfy reliability definitions beyond coverage. This property is leveraged to devise a novel model predictive control (MPC) framework that addresses open-loop and closed-loop control problems under general average constraints on the quality or safety of the control policy. We experimentally validate the performance of PTS-CRC prediction and control by studying a number of use cases in the context of wireless networking. Across all the considered tasks, PTS-CRC predictors are shown to provide more informative predictive sets, as well as safe control policies with larger returns.

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