The highly heterogeneous ecosystem of NextG wireless communication systems calls for novel networking paradigms where functionalities and operations can be dynamically and optimally reconfigured in real time to adapt to changing traffic conditions and satisfy stringent and diverse QoS demands. Open RAN technologies, and specifically those being standardized by the O-RAN Alliance, make it possible to integrate network intelligence into the once monolithic RAN via intelligent applications, namely, xApps and rApps. These applications enable flexible control of the network resources and functionalities, network management, and orchestration through data-driven intelligent control loops. Recent work has showed how DRL is effective in dynamically controlling O-RAN systems. However, how to design these solutions in a way that manages heterogeneous optimization goals and prevents unfair resource allocation is still an open challenge, with the logic within DRL agents often considered as a black box. In this paper, we introduce PandORA, a framework to automatically design and train DRL agents for Open RAN applications, package them as xApps and evaluate them in the Colosseum wireless network emulator. We benchmark $23$ xApps that embed DRL agents trained using different architectures, reward design, action spaces, and decision-making timescales, and with the ability to hierarchically control different network parameters. We test these agents on the Colosseum testbed under diverse traffic and channel conditions, in static and mobile setups. Our experimental results indicate how suitable fine-tuning of the RAN control timers, as well as proper selection of reward designs and DRL architectures can boost network performance according to the network conditions and demand. Notably, finer decision-making granularities can improve mMTC's performance by ~56% and even increase eMBB Throughput by ~99%.

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