We introduce an improved CNOT synthesis algorithm that considers nearest-neighbour interactions and CNOT gate error rates in noisy intermediate-scale quantum (NISQ) hardware. Compared to IBM's Qiskit compiler, it improves the fidelity of a synthesized CNOT circuit by about 2 times on average (up to 9 times). It lowers the synthesized CNOT count by a factor of 13 on average (up to a factor of 162). Our contribution is twofold. First, we define a $\textsf{Cost}$ function by approximating the average gate fidelity $F_{avg}$. According to the simulation results, $\textsf{Cost}$ fits the error probability of a noisy CNOT circuit, $\textsf{Prob} = 1 - F_{avg}$, much tighter than the commonly used cost functions. On IBM's fake Nairobi backend, it matches $\textsf{Prob}$ to within $10^{-3}$. On other backends, it fits $\textsf{Prob}$ to within $10^{-1}$. $\textsf{Cost}$ accurately quantifies the dynamic error characteristics and shows remarkable scalability. Second, we propose a noise-aware CNOT routing algorithm, NAPermRowCol, by adapting the leading Steiner-tree-based connectivity-aware CNOT synthesis algorithms. A weighted edge is used to encode a CNOT gate error rate and $\textsf{Cost}$-instructed heuristics are applied to each reduction step. NAPermRowCol does not use ancillary qubits and is not restricted to certain initial qubit maps. Compared with algorithms that are noise-agnostic, it improves the fidelity of a synthesized CNOT circuit across varied NISQ hardware. Depending on the benchmark circuit and the IBM backend selected, it lowers the synthesized CNOT count up to $56.95\%$ compared to ROWCOL and up to $21.62\%$ compared to PermRowCol. It reduces the synthesis $\textsf{Cost}$ up to $25.71\%$ compared to ROWCOL and up to $9.12\%$ compared to PermRowCol. Our method can be extended to route a more general quantum circuit, giving a powerful new tool for compiling on NISQ devices.

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