The growing global population of older adults, combined with ongoing healthcare workforce shortages, has increased reliance on informal caregivers, including family members and friends who provide unpaid support to individuals with chronic illnesses. Among their daily responsibilities, medication management remains one of the most demanding and error-prone tasks. Non-adherence to prescribed regimens not only undermines patient outcomes but also intensifies caregiver stress, anxiety, and fatigue. Although digital health technologies have proliferated to address adherence, most solutions focus exclusively on patients and neglect the informational and emotional needs of caregivers. This paper introduces Adhera, a caregiver-inclusive health informatics system designed to support medication adherence while reducing caregiver burden. Using a mixed-methods research design that included fifteen semi-structured caregiver interviews, sixty-five survey responses, and five pharmacist consultations, this study identified three primary challenges: caregiver stress related to uncertainty about medication intake, fragmented communication with healthcare professionals, and distrust in existing digital tools. Informed by the CeHRes Roadmap 2.0 and the Triple Bottom Line by Design and Culture (TBLD+C) framework, as well as recent co-design studies involving caregivers, Adhera integrates a sensor-equipped smart pill organizer with a mobile companion application that records intake events, sends real-time reminders, and provides caregivers with synchronized adherence data. Preliminary evaluation suggests that Adhera enhances visibility, improves caregiver confidence, and streamlines medication routines. This study contributes to the field of health informatics by demonstrating how human-centered design and collaborative frameworks can align technical innovation with empathy-driven care.

翻译：全球老年人口持续增长，加之医疗人力资源短缺，使得对非正式照护者（包括为慢性病患者提供无偿支持的亲友）的依赖日益加深。在日常照护职责中，用药管理仍是最具挑战性且易出错的任务之一。不遵循处方用药方案不仅影响患者疗效，还会加剧照护者的压力、焦虑与疲劳。尽管数字健康技术已大量涌现以应对依从性问题，但多数解决方案仅关注患者，忽视了照护者的信息与情感需求。本文介绍Adhera——一个将照护者纳入考量的健康信息系统，旨在支持用药依从性同时减轻照护者负担。通过混合研究方法（包括15次半结构化照护者访谈、65份问卷调查及5次药师咨询），本研究识别出三大核心挑战：照护者因用药不确定性产生的压力、与医疗专业人员沟通碎片化，以及对现有数字工具的不信任。基于CeHRes路线图2.0、设计文化三重底线（TBLD+C）框架及近期包含照护者的协同设计研究，Adhera整合了配备传感器的智能药盒与移动端应用，可记录服药事件、发送实时提醒，并为照护者提供同步的依从性数据。初步评估表明，Adhera能提升用药可视性、增强照护者信心并优化用药管理流程。本研究通过展示以人为本的设计与协作框架如何将技术创新与共情驱动照护相结合，为健康信息学领域作出贡献。