As the use of Deep Neural Networks (DNNs) becomes pervasive, their vulnerability to adversarial attacks and limitations in handling unseen classes poses significant challenges. The state-of-the-art offers discrete solutions aimed to tackle individual issues covering specific adversarial attack scenarios, classification or evolving learning. However, real-world systems need to be able to detect and recover from a wide range of adversarial attacks without sacrificing classification accuracy and to flexibly act in {\bf unseen} scenarios. In this paper, UNICAD, is proposed as a novel framework that integrates a variety of techniques to provide an adaptive solution. For the targeted image classification, UNICAD achieves accurate image classification, detects unseen classes, and recovers from adversarial attacks using Prototype and Similarity-based DNNs with denoising autoencoders. Our experiments performed on the CIFAR-10 dataset highlight UNICAD's effectiveness in adversarial mitigation and unseen class classification, outperforming traditional models.

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