Age-related macular degeneration (AMD) is one of the leading causes of irreversible vision impairment in people over the age of 60. This research focuses on semantic segmentation for AMD lesion detection in RGB fundus images, a non-invasive and cost-effective imaging technique. The results of the ADAM challenge - the most comprehensive AMD detection from RGB fundus images research competition and open dataset to date - serve as a benchmark for our evaluation. Taking the U-Net connectivity as a base of our framework, we evaluate and compare several approaches to improve the segmentation model's architecture and training pipeline, including pre-processing techniques, encoder (backbone) deep network types of varying complexity, and specialized loss functions to mitigate class imbalances on image and pixel levels. The main outcome of this research is the final configuration of the AMD detection framework, which outperforms all the prior ADAM challenge submissions on the multi-class segmentation of different AMD lesion types in non-invasive RGB fundus images. The source code used to conduct the experiments presented in this paper is made freely available.

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