Designing a safe, trusted, and ethical AI may be practically impossible; however, designing AI with safe, trusted, and ethical use in mind is possible and necessary in safety and mission-critical domains like aerospace. Safe, trusted, and ethical use of AI are often used interchangeably; however, a system can be safely used but not trusted or ethical, have a trusted use that is not safe or ethical, and have an ethical use that is not safe or trusted. This manuscript serves as a primer to illuminate the nuanced differences between these concepts, with a specific focus on applications of Human-AI teaming in aerospace system control, where humans may be in, on, or out-of-the-loop of decision-making.

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