The rapid adoption of large language models (LLMs) in enterprise systems exposes vulnerabilities to prompt injection attacks, strategic deception, and biased outputs, threatening security, trust, and fairness. Extending our adversarial activation patching framework (arXiv:2507.09406), which induced deception in toy networks at a 23.9% rate, we introduce the Unified Threat Detection and Mitigation Framework (UTDMF), a scalable, real-time pipeline for enterprise-grade models like Llama-3.1 (405B), GPT-4o, and Claude-3.5. Through 700+ experiments per model, UTDMF achieves: (1) 92% detection accuracy for prompt injection (e.g., jailbreaking); (2) 65% reduction in deceptive outputs via enhanced patching; and (3) 78% improvement in fairness metrics (e.g., demographic bias). Novel contributions include a generalized patching algorithm for multi-threat detection, three groundbreaking hypotheses on threat interactions (e.g., threat chaining in enterprise workflows), and a deployment-ready toolkit with APIs for enterprise integration.

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