In this paper, we propose a novel visual Semantic-Spatial Self-Highlighting Network (termed 3SHNet) for high-precision, high-efficiency and high-generalization image-sentence retrieval. 3SHNet highlights the salient identification of prominent objects and their spatial locations within the visual modality, thus allowing the integration of visual semantics-spatial interactions and maintaining independence between two modalities. This integration effectively combines object regions with the corresponding semantic and position layouts derived from segmentation to enhance the visual representation. And the modality-independence guarantees efficiency and generalization. Additionally, 3SHNet utilizes the structured contextual visual scene information from segmentation to conduct the local (region-based) or global (grid-based) guidance and achieve accurate hybrid-level retrieval. Extensive experiments conducted on MS-COCO and Flickr30K benchmarks substantiate the superior performances, inference efficiency and generalization of the proposed 3SHNet when juxtaposed with contemporary state-of-the-art methodologies. Specifically, on the larger MS-COCO 5K test set, we achieve 16.3%, 24.8%, and 18.3% improvements in terms of rSum score, respectively, compared with the state-of-the-art methods using different image representations, while maintaining optimal retrieval efficiency. Moreover, our performance on cross-dataset generalization improves by 18.6%. Data and code are available at https://github.com/XuriGe1995/3SHNet.

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